Ukungqubuzana phakathi kocwaningo lwakudala nolusungulayo
Inhloso bekuwukuvikela i-OMT ekuboneni kweqembu kanye nomhubhe ngokungqubuzana okwakhayo nokuhlaziya okubucayi.? Inhloso bekuwukuvikela i-OMT ekuboneni kweqembu kanye nomhubhe ngokungqubuzana okwakhayo nokuhlaziya okubucayi., Inhloso bekuwukuvikela i-OMT ekuboneni kweqembu kanye nomhubhe ngokungqubuzana okwakhayo nokuhlaziya okubucayi.? Kuze kube manje, i-Cooperative Health Funds kanye ne-Health Holland ihlela 2017 uphenyo ngaphansi kwegama 'Beter Gezond'. Bakhetha eqenjini labangaphezu kuka 40 I-Cooperative Health Funds kanye ne-Health Holland bahlela isicelo salokhu futhi bakhethe eqenjini labangaphezu kwalokhu, I-Cooperative Health Funds kanye ne-Health Holland bahlela isicelo salokhu futhi bakhethe eqenjini labangaphezu kwalokhu (I-Cooperative Health Funds kanye ne-Health Holland bahlela isicelo salokhu futhi bakhethe eqenjini labangaphezu kwalokhu|I-Cooperative Health Funds kanye ne-Health Holland bahlela isicelo salokhu futhi bakhethe eqenjini labangaphezu kwalokhu).
TvBM_TheoBreuersTimvdGeijn_LD_lr_20200226-1594: TvBM_TheoBreuersTimvdGeijn_LD_lr_20200226-1594
Inhloso: Inani lokuzihlola kwesiguli
Amaqembu eziguli sekunesikhathi ezama ukufaka isandla ekululameni kwawo ngendlela ehlelekile, kubandakanya ngokungenelela ozikhethele yena. Inhloso ye-consortium ukuthuthukisa kanye nokuhlola iphrothokholi yocwaningo olusha ngesibonelelo.
Iziphakamiso ezimbili ezihlobene ziyahlangana lapha: eyodwa evela ku-AMC futhi enye evela enhlanganweni yesiguli MD|I-Cooperative Health Funds kanye ne-Health Holland bahlela isicelo salokhu futhi bakhethe eqenjini labangaphezu kwalokhu. Udokotela wamasosha omzimba e-Amsterdam UMC Anje te Velde kanye nomqondisi we-MD|KANYE noGaston Remmers: “Isiphakamiso sethu esihlanganyelwe sibandakanya indlela ehlelekile yokuthi 'Funda Ngezinhlanzi' olwandle lwedatha kanye nokuqaphela iziguli ezizenzayo nsuku zonke mayelana nempilo yazo.. Sagxila kubantu abanokukhathala okungapheli, ababuye babe nezikhalo zamathumbu. Lelo iqeqebana elikhulu labantu okungekho nhlobo ukungenelela okutholakala kulo njengamanje, kuyilapho laba bantu bezama konke, ngokwesibonelo ukuqinisa amasosha omzimba.”
U-Remmers uyaqhubeka: “Umthetho ozokwenziwa bekumele uvumele ukuthuthukiswa kolwazi oluhlangene ngokusekelwe ekuhloleni kwezempilo okuklanywe izakhamuzi. Laba bantu bathanda ukwazi futhi bazama izinto. Nokho, ososayensi abakwazi ukusebenzisa iningi lalokhu kuhlola, ngoba bathola ukunemba kwesayensi kunganele. Futhi, lezi zakhamuzi azilingani nokuhlolwa komtholampilo okungahleliwe okujwayelekile, ngokuvamile okudingekayo ezivivinyweni eziningi zezokwelapha. Umphumela uba ukuthi empeleni ukungenelela okuningi okunemikhawulo ephansi futhi okungase kube usizo akuliniki ithuba, kuyilapho, ngakolunye uhlangothi, iziguli ziqhubeka nokungenelela okungase kube yingozi.”
iziguli, abacwaningi, Ngakho-ke ababuyekezi bangaphandle kanye nabaxhasi bezimali bayasamukela isiphakamiso sephrojekthi ngesasasa elikhulu, okulindelwe kuphezulu.
Iqembu liqala ukusebenza ukuze likhiqize ubufakazi bomqondo: khombisa ukuthi ucwaningo olwenziwa isakhamuzi ngasinye mayelana nempilo yaso alunikezi nje kuphela ulwazi olubalulekile lona ngokwazo, kodwa futhi nokuthuthukisa ulwazi.
Phakathi naleso sikhathi, sekuvele i-consortium enkulu, ixhaswe ngezimali yi-Cooperating Dutch Health Funds kanye ne-Health Holland (igatsha loMnyango Wezindaba Zomnotho), kanye nezimali eziyisishiyagalombili zezempilo. I-consortium ihlanganisa izikhungo ezine zezemfundo (Amsterdam UMC, Inyuvesi yase-Utrecht, Inyuvesi yase-Amsterdam kanye neMaastricht University), izinkampani ezinhlanu (I-Winclove Probiotics B.V., I-Springfield Nutraceuticals, Isikhungo seMicrobiome, I-Biovis Diagnostics, I-Danone/Nutricia Research) kanye nezinhlangano ezimbili zezakhamizi/zeziguli (Idatha Yami Isisekelo Sezempilo Sethu kanye ne-Holland Health Data Cooperative). Iphrojekthi inobuholi obubili, ihlukaniswe phakathi kososayensi neziguli: Amsterdam UMC (isayensi) kanye ne-My Data Our Health Foundation (iziguli). Le phrojekthi ineBhodi Lochwepheshe Bezesayensi kanye Nebhodi Lochwepheshe Besiguli. Ngamanye amazwi: ukwesekwa kanye nentshisekelo kuphrojekthi kuphezulu kakhulu.
"Besingawathatha ngokungathi sína amafulegi abomvu kusenesikhathi."
Indlela: Isayensi yesakhamuzi njengesengezo ocwaningweni lwakudala
I-MijnEigenOnderzoek iqala ngeqembu elikhulu labantu abanokukhathala okungapheli kanye nezikhalazo zamathumbu.. Ngoba kunzima ukubeka umunwe endaweni ebuhlungu, odokotela abaningi abazi ukuthi benzeni ngalezi ziguli. Okwamanje, laba bantu bavame ukuhamba nezikhalazo zabo iminyaka futhi bazame konke, kuhlanganise nama-probiotics. Kunobufakazi obuqinile besayensi bokuthi ikhwalithi yeflora yamathumbu ihlobene nokukhathala. Kuze kube manje bekunzima ukusungula uxhumano olucacile, ngenxa yokusebenzelana okuningi okuyinkimbinkimbi. Ngakho-ke izifundo zakudala ezingahleliwe nezilawulwa yi-placebo azinikezi isithombe esicacile. Kunzima kakhulu ukunquma imbangela emaphakathi kanye nomphumela, kuyilapho abacwaningi ezingeni ngalinye bebona umehluko omkhulu emiphumeleni.
Izivivinyo ezijwayelekile ezilawulwa ngokungahleliwe (Idatha ye-RCT) uzama ukunciphisa inani lezinto ezisebenzisanayo zibe inombolo elawulekayo nemisiwe. Ngoba imiphumela yalezi zifundo inikeza iziguli inzuzo encane, I-MijnEigenOnderzoek iphakamisa enye indlela yokubuka izinto: vumela ubunkimbinkimbi bubekhona bese ubhala imingcele efanele. Ngaphakathi kwale ndlela, umgomo awukona kakhulu ukunikeza ubufakazi obusheshayo bokusebenza, iphrojekthi ifuna indlela ehlelekile yokukhiqiza imibono engcono yocwaningo lokulandelela oluqinisekisayo.
Kuze kube manje, i-consortium ichaza le ndlela ngezinyathelo ezintathu ezibalulekile:
uhlelo lokuqapha oluqinile: abacwaningi abanesineke bakhetha ukungenelela ngaphansi kokuqondisa kukadokotela. Bachaza izilinganiso zabo zemiphumela ezifanele futhi bazigcine kuhlelo lokusebenza
ukuhlaziya idatha ukuze kuhlonzwe amaqoqo angaphansi afanayo alabo ababizwa ngokuthi abaphenduli nabangewona abangaphenduli
isilingo sakudala esingahleliwe phakathi kweqembu elincane elikhonjiwe ukuphikisa umphumela ocatshangelwayo wokukodwa kokungenelela
Lokhu kwenza indlela yokucabanga izwakale futhi i-MijnEigenOnderzoek inikeza ubufakazi obuhlosiwe bomqondo wendlela ephephile yokwenza ucwaningo ngokungenelela iziguli ezizikhethayo neziziqaphayo ngokwazo.. Isibonelo esihle sesayensi yesakhamuzi.
Ngesikhathi sokucaciswa komqondo wobufakazi, kubonakala sengathi ngokombono wezomthetho ukuhlolwa kwekomidi lokubukeza i-medical-ethical review. (Isinyathelo sifuna ukuhlela kanye nokuqondisa ukuzihlola mayelana nempilo ngendlela enjalo) kuyadingeka. Ikomidi lisichitha ngokuqinile isiphakamiso sokuqala. Ukuze kwenziwe isiphakamiso esibuyekeziwe, iqembu lizibandakanya nezingxoxo nenye i-MREC, okuyinto engavamile neze. Ama-METC amaningi asetshenziselwa ukwamukela isiphakamiso, ukwahlulela lokho, nikeza impendulo futhi yilokho. Lena yindlela abazama ngayo ukubandakanya nokubuza i-METC. Ama-inhibitors: “Besifuna ukucija insingo: uma singakutholi ukugunyazwa, okungenani ukuhlola okubambekayo. “Sibe sesibuya nesiphakamiso sesibili esibukhali kakhulu. Sithumele lokho kwenye i-METC, ngoba sabhekana nokuthanda ubaba okuningi mayelana nombono wesiguli ku-MREC yokuqala. "
“Njengomcwaningi, ungesabi ukukhipha intamo. Qhubeka: okungenani ezigulini.”
Umphumela: Imibono engahambelani ibulala i-MijnEigenResearch
Iqhaza elisemthethweni le-MREC libonakala lingantengantengi: Ama-inhibitors: “Ekugcineni bekumele sivumelane ezintweni ezimbili kuphela: noma wenza i-RCT emsulwa yayo, noma ukhetha ucwaningo lokubheka. Ngenkathi sifuna ukusungula izinto ezintsha kule ndawo, sakha ingxubevange.”
Nokho, i-METC yesibili nayo iyakwenqaba, ngesisusa esibanzi. "Sibone ngokuqinile ukuthi ukusetha okuphambukayo kuphakamisa imibuzo ngokushesha mayelana nohlangothi lwesimilo,” kuqhuba uRemmers. “Siqale ngokuziphatha okuhlukile, nayo idinga indlela ehlukile. Imibono evamile ngalokhu, kungakhathaliseki ukuthi uhlonipheke kangakanani ngokombono we-MREC ngomsebenzi, yamosha indlela yethu.”
Ngemva konyaka nengxenye, ngemva kwemizamo emibili engaphumelelanga yokuthola imvume kumakomiti okubuyekeza izimiso zezokwelapha, abezimali kanye nozakwethu bekhonsortium banquma ukuyimisa iphrojekthi. Ukungezwani phakathi kozakwethu bekhonsortium namakomiti okuhlola kubonakale kukhulu kakhulu. Abakatholana emibonweni yabo nasekukhathazekeni ngezimiso zokuziphatha, indlela kanye nempilo. Iphrojekthi icabange ukuthi ithole indlela phakathi kwemibono engahambelani emazingeni amaningi, kodwa wehluleka ukweqa izindida.
Ngemva kokuma, i-MijnEigenOnderzoek ikhiqize imiphumela emibili emihle.
U-Anje Te Velde uthole isabelomali esivela ku-Amsterdam UMC ukuze aqoke umcwaningi ekuqeqesheni. Manje ucwaninga ngokukhathala ku-IBD (ukuvuvukala kwamathumbu okungapheli), lapho abacwaningi benikeza khona imibuzo ezigulini ukuze kutholwe ukukhathala kwazo futhi badonse igazi ukuze kuhlolwe amasosha omzimba.. Ngakho-ke lokhu kumayelana nengxenye yocwaningo lwe-MijnEigenOnderzoek. Isiphakamiso socwaningo manje sesigunyazwe yiKomidi Lezimiso Zokwelapha.
UGaston Remmers manje usebenza isikhathi esithile eNyuvesi yaseTwente. Lapho uthuthukisa izimo ezizungeze isayensi yesakhamuzi: ungayixhuma kanjani idatha kanye nocwaningo oluvela 'kubantu abavamile' nochwepheshe kanye nenani futhi ubandakanye amakhono okuphenya ezakhamuzi? Ingxenye yomsebenzi wakhe ukujulisa inqubo kanye nemiphumela ye-MijnEigenOnderzoek. Ngaphezu kwalokho, I-Ajenda Yolwazi 'Ucwaningo Lweziguli Nelweziguli' lwenziwa ngaphansi kobuholi be-My Data Our Health Foundation., ngokubambisana nezinye izinhlangano zeziguli futhi egameni le-ZonMw. Ekugcineni, iCitizenScience2Health yazalwa, inkundla kazwelonke yokuziphenya imiphakathi mayelana nezempilo mayelana 15 amaqembu eziguli axhumene amele ndawonye 10.000 abantu.
Isikhungo seMicrobiome, omunye wabalingani be-consortium, yakhe ingqalasizinda emisha yokwelapha kanye nocwaningo ngezisekelo ezakha umqondo we-MijnEigenOnderzoek. Umuthi oqondene nawe ulethwa lapho, ngohlu lomhlaba wonke lwezingxenye ze-probiotic, okuxhunyaniswe nokuqapha komuntu siqu. Kukhona manje ngaphezu 3000 ukwelashwa kweziguli futhi kunesitatimende sokuvuma esivela ku-MREC sokusebenzisa idatha ocwaningweni lokubheka emuva.
Izifundo ezifundiwe: Isiko elingalawuleki mayelana nezimiso zokuziphatha kanye nendlela
Ukwandisa ukwamukela lolu hlobo locwaningo, impikiswano eqhubekayo phakathi kwabantu abathintekayo nezinhlangano mayelana nalezi zindaba iyadingeka. Umqondo wocwaningo olusha kakhulu we-MijnEigenOnderzoek unokuqagela okuningi okumile mayelana nendlela yokwenza., Izimiso zokuziphatha nokuzibandakanya kwesiguli ocwaningweni ngendlela entsha.
“Ngaso leso sikhathi, besingawathatha ngokungathi sína amafulegi abomvu kusenesikhathi, ngoba babekhona ekuseni kakhulu”, kusho uTe Velde. “Ekuqaleni besesivele sathola izimpawu zokuthi ikomidi lezimiso zezokwelapha liyazibuza ukuthi ngabe abantu ku-AMC kufanele yini bafune ukuziphendulela 'ngezindlela ezingenamsebenzi'., odokotela basekhaya nabangenawo.” Ama-inhibitors: “Inhloso yethu bekuwukulwa ngqo nodokotela abangodokotela balapha ekhaya, lokho kwenzeka noma kunjalo, hlinzeka ngombhede ophephile. Sizicabangele ngokweqile ekhonweni lethu lokubhekana nalesi sixwayiso, bekufanele silethe ubuchwepheshe obungcono ngokushesha.” UTe Velde uyengeza kulokho: “Ngesikhathi esifanayo ngiyacabanga manje: Njengomcwaningi, ungesabi ukukhipha intamo yakho. Noma ngabe abantu endaweni bacabanga ukuthi akuyona indawo yakho, qhubeka: okungenani ezigulini.”
Uma ebheka emuva, u-Remmers uyatshela: “Njengabambisene, besizazi izinselelo zesistimu, kodwa sasilazisa ithemba lokuthi umsebenzi wethu wawungedlula lokho. Sahlulela kabi ukuqina nobukhulu baso, futhi babengenangqondo ngomqondo othile”.
“Indlela yokusebenza kwephrojekthi ibilokhu ingena ezicini zesistimu. Lokhu kuhlobene nesiko locwaningo kanye nemibono emile mayelana nezimiso zokuziphatha kanye nendlela yokwenza. Lokhu kuvele ukuthi bekungafinyeleli ngesikhathi esibekiwe sophenyo.”, Kusho uRemmers.
Ama-inhibitors: “Indlela kaMyEigenOnderzoek ibinombono, kodwa kwahamba ukuqonda, ngale kwamakhono namapharadigm emigwamanda yokuhlola. Okubaluleke kakhulu manje ukuthola amaphuzu esihlabathi ngaphezu kwetafula futhi usebenze kancane kancane. Lokhu kudinga ukusebenzisana phakathi kwezinhlangano zeziguli, ohulumeni, ososayensi nosozimali babalulekile.”
Kufanele futhi kube noshintsho lwangempela endleleni iZonMw, I-HealthHolland namanye amaqembu akhipha izingcingo zawo zocwaningo. Ama-inhibitors: “Ezindleleni ezintsha lapho isimilo, indlela yokusebenza kanye nempilo kunendima, akwanele ukwakha uxhaso bese uncika ekubuyekezweni yizigungu ezisunguliwe. Lezi zinhlobo zokusungulwa kwesistimu zidinga ukuhlolwa okuqhubekayo kwamaphoyinti okungqubuzana, ukusheshisa umjikelezo wokufunda.”
Iphuzu le-Einstein (ukubhekana nobunzima): Kube nzima iminyaka ukwenza inkimbinkimbi, ukuphenya amaqembu eziguli ahlukene kakhulu. Ukuntuleka kwemininingwane emisha ekunakekelweni kwala maqembu eziguli kuye kwaholela ekuqondaneni kwemibono phakathi kwezinhlangano ukuze kubhekwane nocwaningo ngendlela entsha..
De canyon (amaphethini agxilile): IKomidi Lokubuyekeza Izimiso Zokuziphatha Kwezokwelapha (Isinyathelo sifuna ukuhlela kanye nokuqondisa ukuzihlola mayelana nempilo ngendlela enjalo) ibona ama-RCT njengohlaka olungcwele locwaningo lwesayensi okufanele kusekelwe kulo ukuhlolwa kokunakekelwa kwezempilo. Ngeshwa, izinkolelo ze-METC bekungamele zihlukane nesiko lamanje locwaningo, ukuze aqine.
Indawo engenalutho etafuleni (akubona bonke abathintekayo abathintekayo): Izinhlangano ezibandakanyekayo ku-MijnEigenOnderzoek kanye nethimba elihola le nhlangano, yehlulekile ukufaka i-METC kuphrojekthi ekuqaleni. Kodwa-ke, baye balawula okungajwayelekile ngokushintsha inqubo evamile ye-METC kusukela ekuhloleni iziphakamiso ukuya ekudaleni ngokubambisana okwengeziwe..
I-post-it (amandla okuthula): Nakuba ithimba elihola umfelandawonye lithathe izinqumo eziwujuqu ezibe nesandla ekutheni kube nomphumela odumazayo, ingabe amalungu eqembu aba nemiphumela engemihle ngemva kokumisa i-MijnEigenOnderzoek?. Isibonelo, izifundo ezimbili zesayensi ziqalwe ngamalungu eqembu ngalinye ngale phrojekthi njengesizathu esiqondile.
