Iko kupokana pakati pechinyakare uye innovative research
Chinangwa chaive chekudzivirira OMT kubva kuboka rekufunga uye mukuona kwemugero.? Chinangwa chaive chekudzivirira OMT kubva kuboka rekufunga uye mukuona kwemugero., Chinangwa chaive chekudzivirira OMT kubva kuboka rekufunga uye mukuona kwemugero.? Kuti izvi zviitike, iyo Cooperating Health Funds uye Hutano Holland inoronga mukati 2017 kubvunza pasi pezita 'Beter Gezond'. Vanosarudza kubva muboka revanopfuura 40 Iyo Cooperating Health Funds uye Hutano Holland inoronga chikumbiro cheizvi uye sarudza kubva muboka revanopfuura, Iyo Cooperating Health Funds uye Hutano Holland inoronga chikumbiro cheizvi uye sarudza kubva muboka revanopfuura (Iyo Cooperating Health Funds uye Hutano Holland inoronga chikumbiro cheizvi uye sarudza kubva muboka revanopfuura|Iyo Cooperating Health Funds uye Hutano Holland inoronga chikumbiro cheizvi uye sarudza kubva muboka revanopfuura).
TvBM_TheoBreuersTimvdGeijn_LD_lr_20200226-1594: TvBM_TheoBreuersTimvdGeijn_LD_lr_20200226-1594
Chinangwa: Kukosha kwekuzviongorora kwemurwere
Mapoka evarwere ave achiedza kwenguva yakati kuti abatsire pakupora kwavo nenzira yakarongeka, kusanganisira kuburikidza nekuzvisarudzira kupindira. Chinangwa chemubatanidzwa ndechekugadzira uye kuyedza tsvakiridzo protocol nerubatsiro.
Zvikumbiro zviviri zvinoenderana zvinosangana pano: imwe kubva ku AMC uye imwe kubva kusangano revarwere MD|Iyo Cooperating Health Funds uye Hutano Holland inoronga chikumbiro cheizvi uye sarudza kubva muboka revanopfuura. Immunologist kuAmsterdam UMC Anje te Velde uye director weMD|Uye Gaston Remmers: "Chikumbiro chedu chakabatana chaisanganisira nzira yakarongeka yekuti 'Dzidza kuHove' mugungwa re data uye zvinoonekwa nevarwere zuva nezuva nezvehutano hwavo.. Taitarisa kune vanhu vaneta kusingaperi, vanewo zvichemo zveura. Iro iboka guru revanhu vasina kana kupindira kuri kuwanikwa parizvino, apo vanhu ava vanoedza zvose, semuenzaniso kusimbisa immune system yavo."
Remmers anoenderera mberi: “Chisungo chaizoitwa chaifanira kugonesa kuvandudzwa kweruzivo rwevanhu maererano neongororo dzehutano dzakagadzirwa nevagari. Vanhu ava vanoda kuziva uye vanoedza zvinhu. Nekudaro, masayendisiti haakwanise kushandisa ruzhinji rwezviedzo izvi, nekuti vanowana kurongeka kwesainzi hakuna kukwana. Zvakare, vagari ava havakodzere zvakajairwa randomized kiriniki miedzo, inowanzodiwa pabvunzo dzekurapa dzakawanda. Mhedzisiro ndeyokuti mukuita zvakawanda zvakaderera-zvikumbaridzo uye zvingangobatsira kupindira hazvimiriri mukana, nepo, kune rumwe rutivi, varwere vanopfuurira nokupindira kunokuvadza.”
varwere, vatsvakurudzi, vaongorori vekunze nevanopa mari saka vanotambira chikumbiro cheprojekiti nechido chikuru, zvinotarisirwa zvakakwirira.
Boka rinotanga kushanda kugadzira humbowo-hwe-pfungwa: ratidza kuti tsvakiridzo yevagari vega vega nezvehutano hwavo haingopi ruzivo rwakakosha ivo pachavo, asiwo pakuvandudza ruzivo.
Panguva ino, mubatanidzwa mukuru wakamuka, inotsigirwa nemari neCooperating Dutch Health Funds uye Hutano Holland (bazi reMinistry of Economic Affairs), pamwe nemari yezvehutano sere. Iyo consortium inosanganisira mana ezvidzidzo nzvimbo (Amsterdam UMC, Yunivhesiti yeUtrecht, Yunivhesiti yeAmsterdam uye Maastricht University), makambani mashanu (Winclove Probiotics B.V., Springfield Nutraceuticals, Microbiome Center, Biovis Diagnostics, Danone/Nutricia Research) uye masangano maviri evagari/varwere (Yangu Dhata Yedu Hutano Hwaro uye iyo Holland Health Data Cooperative). Chirongwa chine hutungamiriri huviri, yakakamurwa pakati pemasayendisiti nevarwere: Amsterdam UMC (sainzi) uye My Data Yedu Hutano Hwaro (varwere). Chirongwa ichi chine Scientific Expert Board uye Patient Nyanzvi Board. Nemamwe mashoko: kutsigirwa uye kufarira mupurojekiti kwakakwirira zvikuru.
"Tingadai takatora mireza mitsvuku kare."
Svika: Citizen sainzi sekuwedzera kune yekirasi tsvagiridzo
MijnEigenOnderzoek inotanga neboka guru revanhu vane kuneta kusingaperi uye kunyunyuta kwematumbo.. Nokuti zvakaoma kuisa munwe wako panzvimbo inorwadza, vanachiremba vazhinji havazivi zvekuita nevarwere ava. Panguva ino, vanhu ava vanowanzofamba nezvichemo zvavo kwemakore uye vanoedza zvose, kusanganisira probiotics. Pane humbowo hwakasimba hwesainzi hunoratidza kuti kunaka kwemaruva emudumbu kunoenderana nekuneta. Kusvika iye zvino zvave zvakaoma kusimbisa kubatana kwakajeka, nekuda kwekudyidzana kwakawanda kwakaoma. Classic randomized uye placebo-inodzorwa zvidzidzo saka hazvipi mufananidzo wakajeka. Zvakaoma kwazvo kuona avhareji causality uye mhedzisiro, nepo vaongorori padanho rega rega vachiona misiyano mikuru mumhedzisiro.
Usual randomized controlled trials (RCT iye) kuyedza kudzikisa huwandu hwezvinhu zvinodyidzana kune inogoneka uye yakamisikidzwa nhamba. Nekuti mhedzisiro yezvidzidzo izvi inopa varwere rubatsiro rushoma, MijnEigenOnderzoek inokurudzira imwe maonero: rega kuoma kuripo uye kunyora ma parameter akakodzera. Mukati memaitiro aya, chinangwa hachizi chakanyanya kupa humbowo hwekuita, iyo purojekiti inoda nzira yakarongeka yekugadzira zvirinani fungidziro yekusimbisa yekutevera tsvagiridzo.
Kuti izvi zviitike, iyo consortium inotsanangura nzira yacho mumatanho matatu akakosha:
a robust monitoring system: vatsvakurudzi vane murwere vanosarudza kupindira pasi pekutarisirwa kwachiremba. Ivo vanotsanangura avo akakodzera mhedzisiro zviyero uye vanoachengeta muapp
ongororo yedata yekuona homogeneous subgroups yevanonzi vanopindura uye vasinga pindure
a classical randomized muedzo pakati peimwe yezvikwata zvakaonekwa kuti zvipikise zvinofungidzirwa mhedzisiro yeimwe yekupindira.
Izvi zvakaita kuti nzira inzwike uye MijnEigenOnderzoek inopa humbowo-hwe-pfungwa yenzira yakachengeteka yekuita tsvagiridzo nekupindira kunosarudzwa nevarwere nekuzviongorora ivo pachavo.. Muenzaniso unoshamisa wesainzi yevagari.
Munguva yekutsanangurwa kwehumbowo-hwe-pfungwa, zvinoita sekunge kubva padanho repamutemo rekuona kuongororwa kwakaitwa nekomiti yezvekurapa-ethical review. (Iyo Cooperative Health Funds uye Hutano Holland yakaronga chikumbiro cheizvi uye yakasarudza kubva muboka revanopfuura) zvinodiwa. Komiti inoramba zvachose chisungo chekutanga. Kugadzira chisungo chakadzokororwa, boka riri kuita nhaurirano neimwe MREC, izvo zvisina kujairika. MaMETC mazhinji anoshandiswa kugamuchira chikumbiro, kutonga izvozvo, ipa mhinduro uye ndizvozvo. Aya ndiwo maitiro avanoedza kubatanidza nekubvunza METC. Remmers: “Taida kupinza badza: kana tikasawana mvumo, ingangoita ongororo yakasimba. “Takazodzoka nechikumbiro chechipiri chakapinza. Takazviendesa kune imwe METC, nekuti takaona hubaba hwakawanda maererano nemaonero emurwere paMREC yekutanga.
“Semuongorori, usatya kuburitsa mutsipa wako kunze. Enderera mberi: kunyanya kune varwere."
Mhedzisiro: Maonero asingaenderane anouraya MijnEigenResearch
Basa repamutemo reMREC rinoratidzika kunge risingazungunuke: Remmers: “Pakupedzisira taifanira kuwirirana mune mbiri chete sarudzo: kana kuti iwe unogadzira RCT yakachena, kana ukasarudza ongororo yekutarisa. Nepo isu taida kuvandudza munzvimbo ino, takanga tagadzira musanganiswa."
Nekudaro, yechipiri METC inorambawo, nekukurudzira kukuru. "Takaona zvakasimba kuti kutsauswa kwemaitiro kumisa kunokurumidza kumutsa mibvunzo nezve chikamu chetsika,” anoenderera mberi Remmers. "Takatanga kubva kune imwe tsika, iyo inodawo nzira yakasiyana. Mafungiro akajairika pamusoro peizvi, zvisinei kuti zvinoremekedzwa sei kubva kuMREC maonero ebasa racho, yakakanganisa maitiro edu."
Kwapera gore nehafu, mushure mekuedza kaviri kukundikana kuwana mvumo kubva kumakomiti ekuongorora tsika dzekurapa, vezvemari uye vemubatanidzwa vemubatanidzwa vanosarudza kumisa chirongwa ichi. Makakatanwa pakati pevadyidzani vemubatanidzwa nemakomiti ekuongorora aratidza kuti akakurisa. Havana kuwana mumwe nemumwe mumaonero avo uye kunetseka pamusoro petsika, nzira uye utano. Iyo purojekiti yakafunga kuti yawana nzira pakati pemafungiro asingaenderane pamatanho mazhinji, asi akatadza kudarika makangaidzo.
Mushure mekumira, MijnEigenOnderzoek yakagadzira maviri akanaka mhedzisiro.
Anje Te Velde akagamuchira bhajeti kubva kuAmsterdam UMC kuti agadze muongorori mukudzidziswa. Iye zvino ari kutsvaga kuneta muIBD (chisingaperi intestinal kuzvimba), uko vatsvakurudzi vanopa mibvunzo kune varwere kuti vaone kuneta kwavo uye kutora ropa rekuedza immunology.. Saka izvi ndezvechimwe chikamu chekutsvagisa kweMijnEigenOnderzoek. Chikumbiro chekutsvagisa chave kutenderwa neMedical Ethics Committee.
Gaston Remmers parizvino anoshanda chikamu-nguva paYunivhesiti yeTwente. Ikoko anovandudza mamiriro ezvinhu akapoteredza sainzi yevagari: ungabatanidza sei data uye tsvagiridzo kubva ku 'vanhu vakarara' nenyanzvi uye kukoshesa uye kuita hunyanzvi hwekuferefeta hwevagari? Chikamu chebasa rake ndechekuwedzera kudzamisa maitiro nemhedzisiro yeMijnEigenOnderzoek. Pamusoro pezvo, Ruzivo Agenda 'Ongororo neVarwere' yakadhirowewa pasi pehutungamiriri hweMy Data Yedu Hutano Hwaro., tichibatsirana nemamwe masangano evarwere uye vakamirira ZonMw. Pakupedzisira, CitizenScience2Health yakazvarwa, chikuva chenyika chekuzviongorora nharaunda dzakapoteredza hutano nezve 15 mapoka evarwere akabatana anomiririra pamwe chete 10.000 vanhu.
Iyo Microbiome Center, mumwe wevabatsiri ve consortium, yakavaka chivako chitsva chekurapa nekutsvaga panheyo dzakagadzira pfungwa dzeMijnEigenOnderzoek.. Mushonga wega wega unounzwa ikoko, nehuwandu hwepasi rose hwezvikamu zveprobiotic, yakabatana nekutarisa kwako pachako. Ikozvino kune akawanda kupfuura 3000 vakarapa varwere uye pane chirevo chekubvumirana kubva kuMREC kushandisa data rekutsvaga kwekutsvaga.
Akadzidza zvidzidzo: Tsika dzisingadzoreki pamusoro petsika uye nzira
Kuwedzera kugamuchira kune rudzi urwu rwekutsvaga, gakava rinoramba riripo pakati pevanhu vakakodzera nemasangano panyaya idzi rinodiwa. Iyo yakanyanya hunyanzvi yekutsvagisa pfungwa yeMijnEigenOnderzoek ine akawanda akamira fungidziro nezve nzira., Ethics uye kubatanidzwa kwemurwere mukutsvaga muchiedza chitsva.
“Panguva imwe cheteyo, tingadai takatora mireza mitsvuku kare kare, nokuti vaivapo mangwanani chaiwo”, anodaro Te Velde. "Pakutanga takatogamuchira zviratidzo zvekuti komiti yezvekurapa yainetseka kuti vanhu veAMC vanofanira kuda kutora mutoro we'nzira dzisina basa' here., quackery uye vanachiremba vekumba." Inhibitors: “Chinangwa chedu chaive chekurwisa vana chiremba vekumba, izvo zvinoitika zvakadaro, kupa mubhedha wakachengeteka. kupa mubhedha wakachengeteka, kupa mubhedha wakachengeteka: kupa mubhedha wakachengeteka: kupa mubhedha wakachengeteka. kupa mubhedha wakachengeteka, kupa mubhedha wakachengeteka: kunyanya kune varwere."
kupa mubhedha wakachengeteka: kupa mubhedha wakachengeteka, asi takakoshesa tariro yokuti chirongwa chedu chaigona kupfuura ichocho. Takafunga zvisizvo kuoma kwayo uye ukuru, uye neimwe nzira vakanga vasina zivo”.
"Maitirwo echirongwa ichi aigara achimhanya mune systemic maficha. Izvi zvine chekuita netsika yekutsvagisa uye maonero akamira pahunhu uye nzira. Izvi zvakaratidza kuve zvisingaverengeki panguva yakapihwa kuferefeta. ", anodaro Remmers.
Remmers: “Maitiro eMyEigenOnderzoek aive nechiono, asi kunzwisisa kwakaenda, kupfuura kugona uye paradigms yemasangano ekuongorora. Chinhu chinonyanya kukosha ikozvino kuwana mapepa ejecha pamusoro petafura uye kushanda zvishoma nezvishoma. Izvi zvinoda kubatana pakati pemasangano evarwere, hurumende, masayendisiti nevane mari vanodiwa.”
Panofanirawo kuve neshanduko chaiyo munzira iyo ZonMw, HealthHolland nemamwe mapato vanoburitsa mafoni avo ekutsvaga. Remmers: "Munzira itsva umo maitiro, nzira uye hutano zvinoita basa, hazvina kukwana kugadzira mari uye wobva wavimba nekuongorora nemasangano akasimbiswa. Aya marudzi ehurongwa hutsva hunoda kuongororwa kunoenderera mberi kwemapoinzi ekukwesha, kuti ukurumidze kutenderera kwekudzidza.”
Iyo Einstein Point (kubata nekuoma kunzwisisa): Zvave zvakaoma kwemakore kuti zvive zvakaoma, kuongorora mapoka evarwere akasiyana. Kushaikwa kweruzivo rutsva mukutarisira mapoka evarwere aya kwakonzera kurongeka kwezviratidzo pakati pemasangano kuti asvike pakutsvagisa nenzira itsva..
De canyon (maitiro akadzika): Dare reMedical Ethics Ongororo (Iyo Cooperative Health Funds uye Hutano Holland yakaronga chikumbiro cheizvi uye yakasarudza kubva muboka revanopfuura) inoona RCTs sechitsvene chekutsvakurudza kwesayenzi iyo kuongororwa kwehutano hwehutano hunofanira kuvakirwa. Nehurombo, kutendwa kweMETC kwaisafanira kutyora tsika yazvino yekutsvagisa, kusimba.
Nzvimbo isina chinhu patafura (haasi ose mapato akakodzera anobatanidzwa): Masangano anobatanidzwa muMijnEigenOnderzoek nechikwata chiri kutungamira iyi consortium, yakundikana kuisa METC muchirongwa ichi pakutanga. Zvakadaro, vakakwanisa kusajairika nekushandura maitiro e METC kubva pakuongorora zvikumbiro kuenda kukugadzira pamwe chete..
Iyo post-iyo (simba re serendipity): Nepo timu inotungamira mubatanidzwa yakaita sarudzo dzeshungu dzakakonzera mhedzisiro inoodza mwoyo, nhengo dzechikwata dzakasangana nemhedzisiro mushure mekumisa MijnEigenOnderzoek?. Semuenzaniso, zvidzidzo zviviri zvesainzi zvakatangwa nenhengo dzechikwata chega nechirongwa ichi sechikonzero chakananga.
